Speaking to WYNC radio, Mayor of New York City Bill de Blasio has raised fears that the city is on the brink of running out of COVID-19 vaccines, stating "We will run out of vaccines next week in New York City if there's not a very different approach from the federal government, the state government and manufacturers."

• A number of senior politicians in various US states are also raising alarms that they are running short of vaccines. Governor Kate Brown of the state of Oregon tweeted: "Last night, I received disturbing news, confirmed to me directly by General Perna of Operation Warp Speed: States will not be receiving increased shipments of vaccines from the national stockpile next week, because there is no federal reserve of doses."

Following up on an earlier bullet (see 1203GMT bullet) the health ministries of a number of countries, including Germany, Norway, and Canada have released statements saying that they have been notified by Pfizer that their shipments of COVID-19 vaccines from the company will fall short of the initial order over the coming weeks.

• The disruption comes as Pfizer seeks to expand its production capacity at its plant in Puurs, Belgium.
• The Pfizer plant in the US is not set to be affected, meaning supply of vaccines there will continue uninterrupted.

Senior EU official Sabine Weyand has stated that the text of the EU-China Comprehensive Agreement on Investment (CAI) will be published next week.

• Speaking to the Center for Strategic and International Studies Weyand, a senior EU trade negotiator from Germany, stated that the EU sees China as a 'cooperative partner, a systemic rival, and an economic competitor'.
• Also says that the CAI should not have come as a 'surprise' to the US, given that the target date of the agreement was public knowledge.
• Says that comparing any level playing field provisions in the CAI to the Trade and Cooperation Agreement with the UK 'makes little sense'.